Lab News

 Posters

Sommers, Noah R.*, Cordova, Ricardo A., Law, Andrew S, Brault, Jeffery J, Pili, Roberto, Wek, Ronald, Staschke, Kirk A. 

Coordination between GCN2 eIF2 kinase and p53 signaling supports purine metabolism and progression of prostate cancer. IUSCCC Cancer Research Day Indiana University Indianapolis, IN May 2, 2024 *Poster

​

Cordova, Ricardo, A.*, R. Sommers, Angela J. Klunk, Roberto Pili, Ronald C. Wek, and Kirk A. Staschke. GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and purine metabolism in prostate cancer. American Society for Cell Biology Cell Bio 23, Boston, MA, December 2 – 6, 2023. Abstract #X. *Poster.

​

Cordova, Ricardo A.*, Noah R. Sommers, Angela J. Klunk, Roberto Pili, Ronald C. Wek, and Kirk A. Staschke. 2023. GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and metabolism in prostate cancer. National Diversity in STEM Conference (SACNAS) Annual Meeting, Portland, OR. October 26 - 28, 2023. *Poster. 

​

Sommers, Noah R.*, Ricardo A. Cordova, Angela J. Klunk, Ronald C. Wek, Kirk A. Staschke. 2023 GCN2 inhibition sensitizes prostate cancer cells to MCL-1 inhibition.Cancer Research Day, Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN. May 4, 2023. *Poster #43.

​

Staschke, Kirk A.*, Ricardo A. Cordova, Noah R. Sommers, Angela J. Klunk, Roberto Pili, and Ronald C. Wek. 2023. GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and metabolism in prostate cancer. Cancer Research Day, Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN. May 4, 2023. *Poster #7.

​

Cordova, Ricardo A.*, May Elbanna, Angela J. Klunk, Christopher Rupert, Li Shen, Yanqing Wang, David Goodrich, Ronald C. Wek, Kirk A. Staschke, Luigi Fontana, and Roberto Pili. Alternate-day fasting enhances the activity of anti-androgen therapy in prostate cancer models. American Association for Cancer Research Annual Meeting. Orlando, FL. April 14 - 19, 2023. Cancer Res (2023) 83 (7_Supplement): 4239. Abstract #4239, *Poster.

​

Cordova, Ricardo A.*, Sean Colligan, Christopher Rupert, Ronald C. Wek, Kirk A. Staschke, and Roberto Pili. Tumor PD-L1 induction associated with dietary protein restriction is modulated by PERK activation. American Association for Cancer Research Annual Meeting. Orlando, FL. April 14 - 19, 2023. Cancer Res (2023) 83 (7_Supplement): 4240. Abstract #4240, *Poster.

​

Cordova, Ricardo A.*, Noah R. Sommers, Angela J. Klunk, Roberto Pili, Ronald C. Wek, and Kirk A. Staschke. GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis in prostate cancer. American Association for Cancer Research Annual Meeting. Orlando, FL. April 14 - 19, 2023. Cancer Res (2023) 83 (7_Supplement): 4818. Abstract #4818, *Poster.

​

Sommers, Noah R.*, Ricardo A. Cordova, Angela J. Klunk, Ronald C. Wek, and Kirk A. Staschke. Targeting GCN2 regulation of amino acid homeostasis sensitizes prostate cancer cells to senolytic therapies. American Association for Cancer Research Annual Meeting. Orlando, FL. April 14 - 19, 2023. Cancer Res (2023) 83 (7_Supplement): 4816. Abstract #4816, *Poster.

Presentations   

​

Sommers, Noah, R.*, Ricardo A. Cordova, Angela J. Klunk, Ronald C. Wek, and Kirk A. Staschke. Identifying synthetic lethality in GCN2 KO tumors using an in vivoCRISPRi screen. Biochemistry and Molecular Biology Research Day, Indianapolis, IN, September 8, 2023. *Oral presentation.

​

Cordova, Ricardo, A.*, R. Sommers, Angela J. Klunk, Roberto Pili, Ronald C. Wek, and Kirk A. Staschke. GCN2 eIF2 kinase and p53 coordinate amino acid homeostasis and purine metabolism in prostate cancer. Biochemistry and Molecular Biology Research Day, Indianapolis, IN, September 8, 2023. *Oral presentation.

​

Cordova, Ricardo A.*, Jagannath Misra, Angela J. Klunk, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Kirk A. Staschke, and Ronald C. Wek. 2023. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Gordon Research Conference, Polyamines in Cancer, Medical Genetics, Aging, Pathogens, and Plants, Waterville Valley, NH. June 25 - 30, 2023. *Oral Presentation.